GCANRX PREPS PHASE II TRIALS ON AUTISM CANNABINOID TREATMENT

With the number of parents self-prescribing CBD for their children’s Autism Spectrum Disorder (ASD) rising, GCANRx has been granted permission to start Phase II Clinical Trials for a cannabinoid treatment from the Israel Ministry of Health.

Dr. Adi Aran will be leading the effort. Aran is a pioneer in Israel when it comes to cannabinoid treatments for autism. The study Aran led into pediatric autism and cannabinoid therapy in 2017 proved a success for the 120 children that took part. 

GCANRx noted this time Aran will focus on studying the safety and efficacy of GCANRx’s neuroprotective cannabinoid therapeutic to treat autism-related spectrum disorders and other conditions like Parkinson’s disease, Alzheimer’s disease, schizophrenia, and epilepsy. The focus however will be that data coming from 4 to 13 years of age using daily oral treatments.

“The primary efficacy objective of the study will be to assess the effect of the neuroprotective therapeutic compared to placebo on behavioral problems, using the Aberrant Behavior Checklist-Irritability Subscale (ABC-I) score – change from baseline to week 12,” GCANRx noted when announcing the new study. 

GCANRx went on to explain that 75 million people around the world have Autism Spectrum Disorder. The lifelong condition impacts 7 million people domestically, 5.4 million of which are adults. Americans spent $268 billion caring for people with ASD in 2015, that number is expected to jump to $461 million by 2025. 

“We are excited to announce that GCANRx has received a final official approval to embark on its Phase II Clinical Trial for our therapeutic aimed at treating ASD and other neuropsychiatric disorders. This significant milestone marks another pivotal moment in our path to develop innovative therapeutic solutions for patients suffering from complex neurological disorders,” said Aitan Zacharin, chief executive officer of GCANRx. “Positive results in this study carry promise for a novel treatment for ASD as well as for other neuropsychiatric disorders such as schizophrenia, Alzheimer’s disease, and Parkinson’s disease, which share similar pathophysiological processes, and can have an enormous impact on the lives of countless families as well as on public health.” 

GCANRx started selling cannabinoid products in Europe in 2018. They had trouble getting wind in their sales. The company believes the move to a more medical approach will be very viable. Especially as more and more parents are choosing to head in this direction to help their kids. 

Zacharin told L.A. Weekly they believe the success they have seen is backboned by the entourage effect. He noted some of the big dogs in international cannabis medicine have been experimenting with THC and CBD isolates in recent years. The reason we haven’t heard about it? The results fail to match the success of more full-spectrum products like what GCANRx is bringing into phase two. 

“Essentially, it’s a combination of therapeutic,” Zacharin said. “It uses cannabinoids, CBD and THC. But it also has some other compounds in it. That alone has also been shown in clinical studies to be effective in treating autism and treating some of the behavioral elements of autism,” Zacharin said before noting the evidence they’ve seen in pretrials. “We actually found that synergistic effect.”

When it finally jumps through all the regulatory hoops, we asked Zacharin if they planned on using natural or synthetic cannabinoids to go to market.

“Natural materials are our focus, which is probably the way to go with you right there. We’ll have to ultimately see how that plays out in the regulatory pathway. That’s something we’re exploring now with advisors,” Zacharin said with the conversation leading back to the lackluster results of synthetic isolates. “With this plant. It’s so complex, so multifaceted. You know that you just can’t eliminate other cannabinoids.”

Is GCANRx at the point where it is fair to say they understand there’s an entourage effect happening but don’t completely understand it? But know that it’s safe enough to bring to market?

“Yeah, undoubtedly,” Zacharin replied. 

YOU CAN’T ENFORCE AWAY LEGAL CANNABIS PROBLEMS

Cannabis operators have faced the short end of the stick time and time again in the legal marketplace, but leaning back on the Drug War tactics of prohibition is never the answer. 

The plague of operators who have never smoked heat in their lives bashing people who never got the shot they wanted in the marketplace continues to grow. Most of the time, the people taking these shots at the traditional underground market are well-funded operators. They use “enforcement of the law” as a catch-all phrase to narc on the streets from state to state. The lack of enforcement, as they see it, is the root of their headaches. This is regardless of their product quality. 

It’s a lot easier to blame someone else to your investors. Those who have been participating in cannabis markets the longest have become the target of that ire. In the worst circumstances, they’d try and convince you all the cannabis grown outside of the legal marketplace is loaded with pesticides that will kill you and sold to you by an international drug trafficking entity. Sure, there’s some nasty weed and sketchy folks in the mix, but painting the entire marketplace with that brush? Sad. Disingenuous. So many things come to mind. 

But here in California, those painters may have pushed us into a new era of enforcement that’s going to bring us back to something a lot closer to the dark ages of cannabis. California’s legalization rollout has gone less than ideal. The original plan to transition the underground market to a new regulated one changed quickly following legalization. 

In the merger of Prop 64 and the state’s forthcoming medical cannabis regulations that would have gone into effect had Prop 64 failed, certain protections for small farmers were lost. The biggest was the prevention of the permit stacking that led to the mega farms that priced mom and pops out of the game on both sides of the market.  

There is a sublayer of people in all this that pretends to hate the underground market while backdooring products from mega grows through sketchy distribution companies. These distributors are the plausible deniability between you and your weed in New York, should shit hit the fan. The mom and pops getting hit the hardest by enforcement this summer rarely will have access to such wider distribution networks technically tapped into the legal market. 

The mechanism for this shitty deliverance will likely be the new Effort to Prevent Illicit Cannabis (EPIC) program. The program is essentially a rebranding of the state’s 40-year-old Campaign Against Marijuana Planting (CAMP). A major difference will be the way the actual enforcement efforts are directed. 

Attorney General Rob Bonta noted when announcing EPIC that his reforms would be focused on the environmental, labor, and economic impacts of illegal cultivation. Much of the resources directed to CAMP went to monitoring the national forests of Northern California for grows during the peak of the growing season, but the EPIC program will have a permanent presence going forward.

One aspect of the program is the fact that it’s expected enforcement on unlicensed gardens located on private parcels will pick up a lot this year. As it destroyed 30 million cannabis plants over the decades, many times there wasn’t anyone in the forest to charge. With the move to heavier enforcement on private parcels, we’re bound to see more people facing legal trouble.

It’s being viewed as a double-edged sword by many up north. As they hear of the risk of enforcement, many laugh, presuming it can’t be anything compared to what they faced during the hardest era of enforcement up north. They also expect the enforcement will see prices bounce back up. 

It might have never gotten to this point of increased enforcement had the farmers had a real shot in the first place. And as the last 40 years have proven, you can’t enforce cannabis out of California, especially when it’s more popular than ever.  

ERYKAH BADU DROPS THAT BADU CANNABIS LINE

In a cannabis industry where much of the time the people of note entering from other walks of life to start their brands have been men, Erykah Badu is about to be one of the most celebrated females ever to enter the space she’s been in since 2020. 

From an outsider’s perspective on the chessboard, it seemed the moves she was making in the build-up to the March 8 launch of her That Badu line at Cookies made a lot of sense. She went with better genetics than some of her peers entering the space and was working with a solid retail partner. We’ve always found that one of the most giant red flags recently is when a celebrity brand launch coincides with the launch of whatever mechanism that’s getting you the weed. Badu went the opposite direction in working with an established retailer. 

That Badu is a cross between Lemonchello and Jet Fuel Gelato. It will be available in eighths and pre-rolls for its International Women’s Day launch on March 8. Expect more offerings from the line in time for Mother’s Day.

Badu’s first cannabis line, Apple Trees, launched in February 2020. Unfortunately, the world closed a few weeks later so the launch got lost in the news that was focused on some of the biggest sales weeks in the history of California cannabis as people feared dispensaries would close. 

But the cannabis world is a lot chiller at this moment with the exception of what small farmers are going through and crime waves. And getting the launch in a month and a half before 4/20 to avoid the noise was a good play, too. 

Our chat with Badu started with the fact she is a busy lady, a multi-platinum recording artist with plenty of things on her plate. What made her want to enter the cannabis space in addition to the wellness work she’d already been involved with for a long time?

“I’ve always been an advocate and interested in cannabinoids,” Badu told L.A. Weekly. “My first band is called The Cannabinoids. We are all on the electronic drum machines, nine of us, and we just improv.”

The conversation quickly moved to her work as a doula she started over 20 years ago and how much that actually intertwined with her new cannabis endeavor over the years. Doulas can assist new families in the build-up, during and after the birthing process, or help families with the transitions that come with death and provide emotional support. 

“I became a doula in 2001 and as a birth and death doula; many of my mothers and patients use cannabis in many different ways,” Badu explained. 

And more personally than those she supports through her doula work, cannabis has long been a part of Badu’s early morning ritual as she works to find alignment for the day or whatever message she needs to hear in that moment.

“It brings clarity, and the aroma is also part of the ritual. The smoking is also a part of the ritual, the breathing, inhaling and blowing and exhaling,” Badu said. “All these things have been very instrumental in my creativity as an artist, as a very busy entrepreneur, and as a mother who has to work in a very masculine world. It helps me not forget who I am and that I am also important.”

Badu is currently a resident of Texas. She is sitting in hopes of the chains moving on legalization in the near future. If people used football metaphors more to try and legalize it, they probably would; nevertheless, Badu is working on a CBD permit. As proven by many in the past, she thinks getting her infrastructure in place with CBD stuff and making the move to recreational when Texas goes legal is the move. Certainly, a fair take. 

Texas isn’t the first place that comes to mind when people think of cannabis reform, but it was a long slow process in many places. Texas is now in the midst of that process — it’s just one of those places that started a bit later. Given this, we asked Badu how private she feels like she has to ever had to be about her own use.

“Exactly. That’s why we can have conversations about it, but we have to be very careful with those types of things,” Badu replied. “So now that it’s being introduced, as a prospective license, we can have more conversations and I will be at the forefront of the legalization. I will use my voice for this. And I’m specifically interested in cannabinoids and women.”

Badu noted, while everything in the product line kind of caters to or comes from a feminine perspective, it’s definitely high-end product meant for whoever wants to smoke heat. But you’ll see plenty of feminine notes, like the packaging mimicking the oriental ceramides Badu has become fond of over the years. 

“I was thinking, what kind of vessel will this be in? What kind of packaging, what colors, with flowers?” Badu said. “I first thought of porcelain and the Oriental and Persian vases and tea sets, and those types of things.”

Badu noted she’s also excited about the mushroom tea she’s working on. We asked what it’s like to be diving into the psychedelic space and if it ever felt like psychedelics had been demonized in communities of color. 

“Maybe demonized is a heavy word, I would say for sure misunderstood,” Badu said.

Badu argues when something is misunderstood, it’s often abused and mishandled. Her new mushroom teas will be called That Badu technologies. The first is meant to be a coffee substitute for during the day and the second is the psychedelic one, which she noted can be used in ritual work of any kind.

Keep an eye out for That Badu to expand across California in 2023.

EMERALD CUP PICKS CALIFORNIA’S FINEST CANNABIS FOR 2023

The Emerald Cup was back for 2023 last weekend and repeat champions weren’t in short supply. 

This year would see the Emerald Cup’s award show move to the Bay Area for the first time after a long stint in wine country before the pandemic and last year’s show at The Montalbán in Hollywood. While nowhere in the state worth having the cup could be considered neutral territory given how many competitors dot the state from north to south, the Bay is one of the better spots to have it because it’s essentially halfway between L.A. and Arcata — most of the state’s cannabis enthusiasts and businesses lie between that two points, too. The venue at Richmond’s Craneway Pavilion was undoubtedly the most gorgeous the cup has seen since it left the redwoods in the early 2010s for bigger venues closer to population centers.  

But the most beautiful sights to behold on the water’s edge were the glass cases filled with this year’s entries. As the judges, contestants and special guests entered the venue, they were greeted by the cases. The flower entries were the most packed, as people wedged in tight to get pics of all the pretty buds for the social media adventures. 

As the award show kicked off, it was like the final countdown to the big categories at the end began. After making its way through some of the more niche photography and product categories, it was on to the social justice awards. In one of the coolest moments of the night, Luke Scarmazzo came on stage to accept The Social Justice Award on behalf of his good friend Weldon Angelos. 

Angelos was released in 2016. He was originally sentenced to serve 55 years over a cannabis conviction with a mandatory minimum sentence but only served 13 years. After his release, Angelos began advocating for others who remained in the circumstances he was able to escape, eventually founding The Weldon Project. One of the people Weldon has helped get out of prison was his close friend Scarmazzo. 

As he took the stage, Scarmazzo noted he was celebrating 100 days since being released from prison after serving 15 years over medical cannabis. The news received one of the loudest ovations of the night. 

Other awards would include The Pioneer Award going to Amber Senter for her work on Social Equity and The Willie Nelson Lifetime Achievement Award going to Mila Jansen for her contribution to the world of hashish over the last 50 years as an entrepreneur, smuggler, and inventor. 

From there we started into the big dog categories of flower and hash. This year’s theme was champions still crushing it. The rest of the evening would feature a carousel of repeat winners or those returning to the podium after a year or two off. 

One of the biggest returns was Ridgeline Farms. After being the only mixed-light cultivator to qualify for the Zalympix finals, the LANTZ hype rolled on this weekend with Ridgeline taking top honors. 

Founder Jason Gellman shared the experience with L.A. Weekly. 

“With all the competition going on these days, The Emerald Cup to me is still the most prestigious and authentic. The judging is taken seriously by a talented group hand-picked for their dedication to the plant,” Gellman said. “As our small cannabis communities have taken a giant hit from the challenges of the industry, it’s as important as ever to stay relevant. I take lots of pride in growing the best herb possible, so when I submit my entries I always feel they have a chance to win.”

After the near-perfect farming conditions up north for most of the last year before monsoon season hit, it was expected Southern Humboldt would be very competitive. Most of the years that a NorCal farmer didn’t win the cup it had something to do with mother nature. Gellman was proud to see what the county did this year. 

“This year, Humboldt County showed up big. Winning is huge, but it’s more about us representing our community as a whole than just one of us,” Gellman said. “Ridgeline took home multiple awards including first in mixed light with my new strain LANTZ, but what we were the most proud of is winning the Breeders cup.” 

Gellman had been working on creating this strain for over four years. 

“Lots of time, energy, money, fails and finally one giant win,” Gellman said. “I knew LANTZ was the one, but this just solidifies it. The cup was a giant success this year and was great to see so many real heads in the game. Overall, it was a great day in the bay” 

Rebel Grown took home top honors in the Full Sun. After regularly gracing the top 10 and top 20 over the years, this time they were able to take first place with their Double OG Chem. 

In indoor, Fig Farms would became the only indoor farm to ever win The Emerald Cup twice after now winning both the past two renditions of the contest. The Blue Face that won the indoor category was also the first-ever indoor flower to win The Emerald Cup’s prestigious best-in-show award. 

“The love we received at the Emerald Cup has elevated to a new level,” Keith Healy of Fig Farms told L.A. Weekly, “Two years at the top spot for indoor flower, and this year going a step further by receiving Best in Show. Fig Farms’s Blue Face is the first indoor flower to receive the Best in Show award, which has been given exclusively to Sungrown flower until now. I am so proud of our team, and truly honored in a way that cannot be put into words.”

Here are the 2023 Winners:

Sungrown Flower

Mixed Light Flower

Indoor Flower

Sungrown Greenhouse Flower

Personal Use Flower

Pre-Roll

Solventless Concentrates

Cartridges

Solvent Concentrates

Topical

Tincture

Edibles

Alternative Cannabinoids

THE CANNABIS TRENDS WE’RE BUYING IN 2023

This week we’re excited about what’s to come for the cannabis industry in 2023. 

Last week we covered the fact that life is less than perfect in cannabis while highlighting some of the things we believed caused a lot of our headaches in 2022. This week, the opposite. We’re highlighting the things we think are going to help everyone turn it around. 

Finally Fixing LA’s Equity Program 

Here in Los Angeles, one of the biggest calls to action from the cannabis industry for the new mayor’s office continues to be the repair of the L.A. Social Equity Program. It was awesome to see 100 Social Equity Individual Applicants were randomly selected to apply for retail cannabis licenses last month, but the couple hundred people who invested their lives into putting their ducks in a row for the program are going to demand more. And while the new mayor’s office is separate from the scandals of the fall, they may have to pay the bill if a class action lawsuit ends up developing from the then-racist city council having original control over the program that drained so many coffers. 

Standardized Testing?

It originally looked like we would have standardized lab testing this year. It seems a little hazy at the moment, but we wanted to put it on here to push the idea. Currently, cannabis labs have no fixed standard operating procedures. A lot of the time they’re just following the instructions for whatever hardware they bought. Then adjust the standard operating procedure to their liking. That’s where you see the variations in testing numbers from lab to lab. The idea of people shopping around their cannabis at labs to get the best numbers possible is a real thing. This is more so an issue with potency and terpene testing as opposed to heavy metals and pesticides.

Wider Access in America

It’s critical that California cultivators get access to more shelf space soon. While the state continues to drag a bit, the idea of stocking shelves all over the world with cannabis grown in California is appealing to people. The first shelves will probably be domestic, and step one is having as many states with legal access to cannabis as possible for when that day comes. And it’s not that far out. Some regulators figure it will be a few more years. Whenever it is, it’ll certainly make people’s lives a lot easier. We don’t think it will happen this year, but we’ll be talking about the mechanics of it by December a lot. 

The Pace of Change is Fast

I know it’s going to take some time for the other stuff I mentioned, but it’s easy to see how fast things are moving for cannabis all over the world. It’s like a snowball with a rocket sled behind it pushing it even faster as it grows and grows rolling down the mountain. Now is everyone hoping to get sucked up by the snowball a saint? Doubtful. But the bigger the snowball gets, the more opportunities there will be for nice people to take part. Plenty of people entering the cannabis space now aren’t haters, they were just scared to go to jail back in the day. 

MEDICAL CANNABIS PRISONER LUKE SCARMAZZO FREE

Luke Scarmazzo was California’s most prominent medical cannabis operator serving federal time and he did so for nearly 15 years until his release on Feb. 3. 

For those many years, Scarmazzo served as the face of the worst-case scenario for state’s medical cannabis operators. He was walking proof that even if you were operating in full compliance with state law, the feds could come to rip you away from your family at any moment. 

There is a fair argument to be made that of the cannabis offenders released in recent years to much-deserved excitement, Scarmazzo was the most connected to the modern industry. Modesto, the home of the nonprofit California Healthcare Collective (CHC) for its year in operation, is now riding its own cannabis wave that hit the shore a bit later than coastal California. We even covered cannabis sales at the Modesto Reservoir during Dirtybird Campout.  

After giving him some room to catch up with family and friends, we caught up with Scarmazzo last weekend. 

The conversation would start with the fact he’d been the main face of California medical cannabis prisoners since the release of Eddy Lepp in 2016. But the two were on very different boats. Scarmazzo operated a nonprofit collective while Eddy grew some legendary “smell it from the highway” big crops. Eddy pushed the limits and many of his peers up north weren’t as surprised when he caught a case even though he was compliant with state law. Scarmazzo on the other hand represented a lot more people doing exactly what he was doing that didn’t want to end up in similar circumstances. As such, he’s had a lot of different people and organizations advocating for his release throughout his whole incarceration. With Eddy it was more of a cult hero support, but I can’t imagine most of those supporting Lepp thought they’d ever go as big as he did. 

So with all that, when did Scarmazzo know this time it was real? The day he was released. 

“I woke up, kind of just did the normal prison routine,” Scarmazzo told L.A. Weekly. “I gotta make coffee, getting ready to work out. And I just kind of go jump on the email to check the day’s emails.”

When he logged in there were significantly more emails in there than usual.

“So I knew something was up,” Scarmazzo said. “So I was like, OK, so I open it up. And the first email I see is from my attorney, and the subject line says, ‘you’re a free man.’ So I just stared at the computer for a few minutes.”

Things got a bit more obvious in 2017 that Scarmazzo was getting targeted for more time over his music career where he’d taken some shots at the feds in his lyrics. In January of that year, Scarmazzo’s co-defendant, Ricardo Montes, had his sentence commuted by President Obama on his way out the door. Scarmazzo, who also applied, wasn’t as lucky. And given the nature of how clemency works he never found out why, but to onlookers, it seemed pretty obvious. 

The pair had worked on their clemency petitions in an informal clemency clinic in the prison library where Scarmazzo and Mission Green founder Weldon Angelos would help guys file their petitions and legal documents for free. Scarmazzo had wrapped his head around legal forms and paperwork over the first five years of his sentence on the hunt to find a way out. He was essentially offering up the skill set he’d built in that time to other prisoners free of charge. 

“So we did this kind of clemency clinic, and then we, when it came to our turn to file, Weldon and I worked on both mine and Ricardo’s clemency petition,” Scarmazzo said. “They’re basically identical petitions. I mean, we were sitting together, and we were charged the same. We were both co-founders of CHC. So it was like, our conduct and all the circumstances of our case were pretty much the same.”

Scarmazzo noted the petitions were identical to the point all he had to do was swap out his name and personal information. 

Scarmazzo would see Montes’ name among those granted clemency, but not his own. That was seemingly the point it felt the most personal. 

“I knew something like this has to be something personal, I mean, this has to be an issue that’s directed directly at me, rather than us because the president obviously granted his and then called his sentence outdated and unjust. And I’m like, well, hello, my sentence is the same. So if you think this is outdated, adjust my findings, too.”

Scarmazzo reiterated he was happy to see Montes walk. The pair had been friends for many years before their ordeal. But he remembers one of the low points of the moment is having to explain the situation to his daughter. 

“I was really happy to see him get out though,” Scarmazzo said. “He’s my brother. I’ve known Ricardo since we were kids. So, but you know, it was bittersweet. Like it was hard to kind of, I guess the hardest part was calling my family and my daughter and just telling them, hey it didn’t come through for us, but it came through for Ricardo. I want everybody to be happy for him.”

He knew regardless of his own circumstances, the moment had to be treated like it was a big win, because it was.

Most of the federal actions that followed what happened to Scarmazzo felt targeted. The last major federal action on a cannabis retailer operating in compliance with state law was 11 years ago during the Oaksterdam raids. Its founder, Richard Lee, bankrolled Proposition 19 in 2010 with legalization, only losing by a few points. The feds got their revenge on him a couple of years later. 

One of the things Scarmazzo is most thankful for is the 29-page opinion the judge wrote when granting a five-year supervised release for the rest of his sentence. The long document articulates the changing of the times and other people will be able to use it as case law in their own quests for freedom. 

The team at the nation’s oldest cannabis law reform group, The National Organization for The Reform of Marijuana Laws, was happy for what Scarmazzo’s freedom meant in the continued wave of cannabis prisoners getting out in recent years.

“I think it definitely sets a fantastic precedent that we’re starting to see federal judges reexamine the sentences that have been handed out by other judges, or sometimes even by themselves,” NORML Political Director Morgan Fox told L.A. Weekly. “When they start to look at changes of both state and federal policy and as well as the length of sentences that had been handed down for violations of federal infractions over the years since national attitudes have been changing.”

Fox noted there’s a lot of people out there that don’t have the connections and resources that might get lost in the shuffle here. 

“And at the same time, there’s also just the opinion of one judge in one particular case,” Fox said. “It’s really going to take a change in federal law in order to start providing relief on a massive scale for not only people at the federal level, but people at the state level.”

California NORML called Scarmazzo the last known federal medical marijuana prisoner, following his release.